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Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction

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Abstract

A copper-catalysed tandem decarboxylation/aldol reaction of simple aromatic aldehydes with 2,2-difluoro-3-oxo-3-arylpropanoic acid has been developed under mild conditions. This method provides a new route for the direct one-pot synthesis of difluorinated aldols in moderate to good yields from simple substrates.

Graphical abstract: Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction

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Publication details

The article was received on 15 Jul 2017, accepted on 29 Aug 2017 and first published on 29 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01739A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction

    J. Yuan, S. Liu and W. Mai, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01739A

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