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Organocatalytic condensation–ring opening–annulation cascade reactions between N-Bocindolin-2-ones/benzofuran-2(3H)-ones and salicylaldehydes for synthesis of 3-arylcoumarins

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Abstract

An organocatalytic cascade synthesis of 3-arylcoumarins has been developed. Mediated by 1,8-diazabicyclo[5,4,0]-undec-7-ene or tetramethylguanidine, a number of 3-arylcoumarins were obtained in good to excellent yields via condensation–ring opening–annulation between N-Bocindolin-2-ones/benzofuran-2(3H)-ones and salicylaldehydes. This method was featured by a broad scope of reactants, mild conditions, and simple operation.

Graphical abstract: Organocatalytic condensation–ring opening–annulation cascade reactions between N-Bocindolin-2-ones/benzofuran-2(3H)-ones and salicylaldehydes for synthesis of 3-arylcoumarins

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Publication details

The article was received on 14 Jul 2017, accepted on 26 Jul 2017 and first published on 26 Jul 2017


Article type: Communication
DOI: 10.1039/C7OB01730H
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Organocatalytic condensation–ring opening–annulation cascade reactions between N-Bocindolin-2-ones/benzofuran-2(3H)-ones and salicylaldehydes for synthesis of 3-arylcoumarins

    Y. Cheng, P. Zhang, Y. Jia, Z. Fang and P. Li, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01730H

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