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Synthesis of 4-benzylpyridines via Pd-catalyzed CH3-arylation of 4-picoline

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Abstract

A highly efficient synthesis of 4-benzylpyridines was developed via Pd-catalyzed C(sp3)–H arylation between 4-picoline and aryl halides. It was found that the best yields were achieved with a simple Pd(PPh3)4 catalyst and Cs2CO3 as the base. Compared with the known methods, our reaction does not require the use of a strong organometallic reagent as the base.

Graphical abstract: Synthesis of 4-benzylpyridines via Pd-catalyzed CH3-arylation of 4-picoline

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Publication details

The article was received on 13 Jul 2017, accepted on 24 Aug 2017 and first published on 24 Aug 2017


Article type: Communication
DOI: 10.1039/C7OB01726J
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Synthesis of 4-benzylpyridines via Pd-catalyzed CH3-arylation of 4-picoline

    J. Wu, D. Wang, X. Chen, Q. Gui, H. Li, Z. Tan, G. Huang and G. Wang, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01726J

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