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Issue 33, 2017
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“On water” catalytic enantioselective sulfenylation of deconjugated butyrolactams

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Abstract

The first catalytic enantioselective α-sulfenylation of deconjugated butyrolactams has been developed using dimeric cinchona alkaloids as catalysts in a water-enriched reaction medium. Highly substituted and densely functionalized γ-lactams, bearing a quaternary stereogenic center, are produced with up to 99.5 : 0.5 er. The applicability of the same catalyst system for the enantioselective α-selenylation and formal vinylogous γ-hydroxylation of deconjugated butyrolactam has also been described.

Graphical abstract: “On water” catalytic enantioselective sulfenylation of deconjugated butyrolactams

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Publication details

The article was received on 12 Jul 2017, accepted on 18 Jul 2017 and first published on 18 Jul 2017


Article type: Paper
DOI: 10.1039/C7OB01714F
Citation: Org. Biomol. Chem., 2017,15, 6921-6925
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    “On water” catalytic enantioselective sulfenylation of deconjugated butyrolactams

    S. J. Singha Roy and S. Mukherjee, Org. Biomol. Chem., 2017, 15, 6921
    DOI: 10.1039/C7OB01714F

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