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Application of α-amino acids for the transition-metal-free synthesis of pyrrolo[1,2-a]quinoxalines

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Abstract

A practical and concise protocol for the efficient synthesis of pyrrolo[1,2-a]quinoxalines from readily available α-amino acids and 2-(1H-pyrrol-1-yl)anilines under transition metal-free conditions has been established. This protocol, which includes the formation of new C–C and C–N bonds, features a wide substrate scope with a broad range of functional group tolerance.

Graphical abstract: Application of α-amino acids for the transition-metal-free synthesis of pyrrolo[1,2-a]quinoxalines

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Publication details

The article was received on 10 Jul 2017, accepted on 04 Aug 2017 and first published on 04 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01688C
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Application of α-amino acids for the transition-metal-free synthesis of pyrrolo[1,2-a]quinoxalines

    H. Liu, F. Zhou, W. Luo, Y. Chen, C. Zhang and C. Ma, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01688C

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