Jump to main content
Jump to site search


Metal-free cascade reaction of β-halo-α,β-unsaturated aldehyde and 1,4-dithiane-2,5-diol: synthesis of polycyclic 2-formylthiophenes

Abstract

A metal-free cascade reaction strategy has been developed for the synthesis of novel polycyclic 2-formylthiophenes from β-halo-α,β-unsaturated aldehydes and 1,4-dithiane-2,5-diol. Recyclable polymer supported organic base was used to perform the reaction process. This synthetic protocol was applied to synthesize several novel polycyclic thiophenes including steroidal D-ring annelated thiophene. Our synthetic strategy provides high yield of thiophenes, avoids tedious work-up procedure and minimizes the formation of waste.

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jul 2017, accepted on 13 Jul 2017 and first published on 13 Jul 2017


Article type: Communication
DOI: 10.1039/C7OB01641G
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
  •   Request permissions

    Metal-free cascade reaction of β-halo-α,β-unsaturated aldehyde and 1,4-dithiane-2,5-diol: synthesis of polycyclic 2-formylthiophenes

    L. Goswami, K. Neog, K. Sharma and P. Gogoi, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB01641G

Search articles by author

Spotlight

Advertisements