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Issue 33, 2017
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Solvent controlled radical cyclization of propargylamines for multi-iodinated quinoline formation

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Abstract

A solvent controlled regioselective metal-free synthesis of iodo-substituted N-heterocycles has been developed. This protocol undergoes a cascade iodination/cyclization/oxidation/aromatization pathway to afford multi-halogenated quinolines from readily available propargylamines under mild conditions.

Graphical abstract: Solvent controlled radical cyclization of propargylamines for multi-iodinated quinoline formation

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Publication details

The article was received on 05 Jul 2017, accepted on 31 Jul 2017 and first published on 31 Jul 2017


Article type: Communication
DOI: 10.1039/C7OB01637A
Citation: Org. Biomol. Chem., 2017,15, 6901-6904
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    Solvent controlled radical cyclization of propargylamines for multi-iodinated quinoline formation

    Y. Zhang, X. Liu, Z. Wu, Y. Wang and Y. Pan, Org. Biomol. Chem., 2017, 15, 6901
    DOI: 10.1039/C7OB01637A

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