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Rhodium(III)-catalyzed and MeOH-involved regioselective mono-alkenylation of N-arylureas with acrylates

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Abstract

We herein disclose, for the first time, Rh(III)-catalyzed and MeOH-involved regioselective mono-alkenylation of arenes with acrylates using NHCONMe2 as the transformable directing group, giving direct access to diverse ortho-acrylated N-phenyl carbamates. The synthetic application of the obtained products to build privileged quinolin-2(1H)-ones and 3-(2-aminophenyl)acrylates has also been demonstrated in subsequent derivatization reactions.

Graphical abstract: Rhodium(iii)-catalyzed and MeOH-involved regioselective mono-alkenylation of N-arylureas with acrylates

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Publication details

The article was received on 04 Jul 2017, accepted on 31 Jul 2017 and first published on 31 Jul 2017


Article type: Communication
DOI: 10.1039/C7OB01627A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Rhodium(III)-catalyzed and MeOH-involved regioselective mono-alkenylation of N-arylureas with acrylates

    H. Lv, J. Shi, J. Huang, C. Zhang and W. Yi, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01627A

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