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New bioluminescent coelenterazine derivatives with various C-6 substitutions

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Abstract

A series of new coelenterazine analogs with varying substituents at the C-6 position of the imidazopyrazinone core have been designed and synthesized for the extension of bioluminescence substrates. Some of them display excellent bioluminescence properties compared to DeepBlueC™ or native coelenterazine with both in vitro and in vivo biological evaluations, thus placing these derivatives among the most ideal substrates for Renilla bioluminescence applications.

Graphical abstract: New bioluminescent coelenterazine derivatives with various C-6 substitutions

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Publication details

The article was received on 26 Jun 2017, accepted on 28 Jul 2017 and first published on 31 Jul 2017


Article type: Paper
DOI: 10.1039/C7OB01554B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    New bioluminescent coelenterazine derivatives with various C-6 substitutions

    T. Jiang, X. Yang, Y. Zhou, I. Yampolsky, L. Du and M. Li, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01554B

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