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Issue 35, 2017
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Aerobic thiyl radical addition/cyclization of N-methacryloyl benzamides for the synthesis of isoquinoline-1,3(2H,4H)-dione derivatives

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Abstract

A highly effective oxidative thiyl radical addition/cyclization of N-methacryloylbenzamides was explored using dioxygen as the sole terminal oxidant without the use of precious and/or toxic transition-metal catalysts. This method provides convenient access to a variety of useful sulfide-containing 4,4-disubstituted isoquinoline-1,3-diones by constructing C–S and C–C bonds in one step.

Graphical abstract: Aerobic thiyl radical addition/cyclization of N-methacryloyl benzamides for the synthesis of isoquinoline-1,3(2H,4H)-dione derivatives

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Publication details

The article was received on 26 Jun 2017, accepted on 10 Aug 2017 and first published on 10 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01552F
Citation: Org. Biomol. Chem., 2017,15, 7330-7338
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    Aerobic thiyl radical addition/cyclization of N-methacryloyl benzamides for the synthesis of isoquinoline-1,3(2H,4H)-dione derivatives

    Y. Yuan, P. S. Kumar, C. Zhang, M. Yang and S. Guo, Org. Biomol. Chem., 2017, 15, 7330
    DOI: 10.1039/C7OB01552F

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