Jump to main content
Jump to site search


Aerobic Thiyl Radical Addition/Cyclization of N-Methacryloyl Benzamides for the Synthesis of Isoquinoline-1,3(2H,4H)‑dione Derivatives

Abstract

A highly effective oxidative thiyl radical addition/cyclization of N-methacryloylbenzamides was explored using dioxygen as the solely terminal oxidant without the use of precious and/or toxic transition-metal catalysts. This method provides convenient access to a variety of useful sulfide-containing 4,4-disubstituted isoquinoline-1,3-diones by constructing C-S and C-C bonds in one step.

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Jun 2017, accepted on 10 Aug 2017 and first published on 10 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01552F
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
  •   Request permissions

    Aerobic Thiyl Radical Addition/Cyclization of N-Methacryloyl Benzamides for the Synthesis of Isoquinoline-1,3(2H,4H)‑dione Derivatives

    Y. Yuan, P. S. Kumar, C. zhang, M. Yang and S. guo, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB01552F

Search articles by author

Spotlight

Advertisements