Issue 33, 2017
From the journal:

Organic & Biomolecular Chemistry

Enzyme-instructed self-assembly with photo-responses for the photo-regulation of cancer cells†

Zhengquan Zhou,a   Xian Xie,a   Qikun Yi,a   Wencui Yin,b   Adnan A. Kadi,b   Jinbo Li ORCID logo *a  and  Yan Zhang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: njuzy@nju.edu.cn, jinboli@nju.edu.cn

b Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia

Abstract

Using a short peptide precursor modified by the biaryltetrazole with intramolecular photo-click reactivity, we realized the photo-regulation of the pericellular nanofibers formed by the enzyme-instructed self-assembly on the cell membrane. Upon light irradiation, the fluorescence of nanofibers could be turned on to monitor both enzyme-instructed self-assembly and photo-induced disassembly processes. Moreover, the cell fate could be controlled through the photo-regulation.

Graphical abstract: Enzyme-instructed self-assembly with photo-responses for the photo-regulation of cancer cells

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Article information

DOI
https://doi.org/10.1039/C7OB01548H
Article type
Communication
Submitted
26 Jun 2017
Accepted
25 Jul 2017
First published
25 Jul 2017

Org. Biomol. Chem., 2017,15, 6892-6895

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Enzyme-instructed self-assembly with photo-responses for the photo-regulation of cancer cells

Z. Zhou, X. Xie, Q. Yi, W. Yin, A. A. Kadi, J. Li and Y. Zhang, Org. Biomol. Chem., 2017, 15, 6892 DOI: 10.1039/C7OB01548H

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