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Issue 29, 2017
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Pd-Catalyzed regioselective C–H halogenation of quinazolinones and benzoxazinones

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Abstract

A Pd-catalyzed ortho-selective halogenation of benzoxazinone and quinazolinone scaffolds has been described employing N-halosuccinimide as both a halogen source and an oxidant reagent via C–H bond activation. This transformation shows high chemo- and regioselectivities and demonstrates a broad range of benzoxazinone and quinazolinone substrates with different functional groups and has been scaled up to the gram level.

Graphical abstract: Pd-Catalyzed regioselective C–H halogenation of quinazolinones and benzoxazinones

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Publication details

The article was received on 23 Jun 2017, accepted on 05 Jul 2017 and first published on 05 Jul 2017


Article type: Paper
DOI: 10.1039/C7OB01534H
Citation: Org. Biomol. Chem., 2017,15, 6264-6268
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    Pd-Catalyzed regioselective C–H halogenation of quinazolinones and benzoxazinones

    M. Dabiri, N. Farajinia Lehi, S. Kazemi Movahed and H. R. Khavasi, Org. Biomol. Chem., 2017, 15, 6264
    DOI: 10.1039/C7OB01534H

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