Jump to main content
Jump to site search

Issue 33, 2017
Previous Article Next Article

A hybrid molecule of a GFP chromophore analogue and cholestene as a viscosity-dependent and cholesterol-responsive fluorescent sensor

Author affiliations

Abstract

Diarylmethylenated and cholestene (or -tane)-hybrid analogues of the GFP chromophore, namely, Ch-DAINs were successfully synthesised by a condensation reaction between methyl imidates and N-(diarylmethylene)glycinates. Among the Ch-DAINs synthesised, a diphenyl-type analogue showed viscosity-dependent and cholesterol-responsive fluorescent properties. It showed a nearly linear increase of the fluorescence emission in triglycerides and vesicles as the amount of cholesterol was increased.

Graphical abstract: A hybrid molecule of a GFP chromophore analogue and cholestene as a viscosity-dependent and cholesterol-responsive fluorescent sensor

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jun 2017, accepted on 01 Aug 2017 and first published on 01 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01522D
Citation: Org. Biomol. Chem., 2017,15, 6948-6958
  •   Request permissions

    A hybrid molecule of a GFP chromophore analogue and cholestene as a viscosity-dependent and cholesterol-responsive fluorescent sensor

    M. Ikejiri, K. Mori, R. Miyagi, R. Konishi, Y. Chihara and K. Miyashita, Org. Biomol. Chem., 2017, 15, 6948
    DOI: 10.1039/C7OB01522D

Search articles by author

Spotlight

Advertisements