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Issue 41, 2017
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Tetrasubstituted cyclopentadienones as suitable enantiopure ligands with axial chirality

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Abstract

A series of thermally stable atropisomeric phencyclone ligands (ΔGrac > 35 kcal mol−1), bearing two chiral axes, has been successfully synthesized, taking into account the results of DFT calculations on model systems. The absolute configurations of the novel atropisomers have been assigned using TD-DFT simulation of ECD spectra. Atropisomeric phencyclones herein presented pave the way towards new ruthenium-based enantioselective hydrogenation catalysts.

Graphical abstract: Tetrasubstituted cyclopentadienones as suitable enantiopure ligands with axial chirality

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Publication details

The article was received on 15 Jun 2017, accepted on 11 Sep 2017 and first published on 11 Sep 2017


Article type: Paper
DOI: 10.1039/C7OB01455D
Citation: Org. Biomol. Chem., 2017,15, 8720-8728
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    Tetrasubstituted cyclopentadienones as suitable enantiopure ligands with axial chirality

    L. Prati, M. Mancinelli, A. Ciogli and A. Mazzanti, Org. Biomol. Chem., 2017, 15, 8720
    DOI: 10.1039/C7OB01455D

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