Jump to main content
Jump to site search


Copper-catalyzed synthesis of arylcarboxamides from aldehydes and isocyanides: the isocyano group as an N1 synthon

Author affiliations

Abstract

An interesting radical coupling reaction of aromatic aldehydes with isocyanides was disclosed for the synthesis of amides catalyzed by copper. According to the experimental results and mechanistic study, the isocyano group acted as an N1 synthon rather than exhibiting the carbene-like reactivity, exploiting a new reactivity profile of isocyanides.

Graphical abstract: Copper-catalyzed synthesis of arylcarboxamides from aldehydes and isocyanides: the isocyano group as an N1 synthon

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Jun 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Communication
DOI: 10.1039/C7OB01449J
Citation: Org. Biomol. Chem., 2017, Advance Article
  •   Request permissions

    Copper-catalyzed synthesis of arylcarboxamides from aldehydes and isocyanides: the isocyano group as an N1 synthon

    J. Liu, X. Shen, Z. Liu and X. Wang, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01449J

Search articles by author

Spotlight

Advertisements