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Issue 28, 2017
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Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature

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Abstract

A highly regioselective direct C2-acylation of N-pyrimidine protected indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(II) catalysis. Late-stage acylation of tryptophan, selective mono-acylation of carbazole and the syntheses of tubulin inhibitors D-64131 and D-68144 are also demonstrated.

Graphical abstract: Dual visible-light photoredox and palladium(ii) catalysis for dehydrogenative C2-acylation of indoles at room temperature

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Publication details

The article was received on 12 Jun 2017, accepted on 27 Jun 2017 and first published on 27 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01418J
Citation: Org. Biomol. Chem., 2017,15, 5899-5903
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    Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature

    M. K. Manna, G. Bairy and R. Jana, Org. Biomol. Chem., 2017, 15, 5899
    DOI: 10.1039/C7OB01418J

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