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Low pH-triggering changes in peptide secondary structures

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Abstract

We developed a novel methodology using cyclic α,α-disubstituted α-amino acids (dAAs) with an acetal-side chain to control peptide secondary structures. The introduction of cyclic dAAs into peptides contributed to the stabilization of peptide secondary structures as a helix, while an acidic treatment of peptides resulted in a marked conformational change.

Graphical abstract: Low pH-triggering changes in peptide secondary structures

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Publication details

The article was received on 06 Jun 2017, accepted on 27 Jun 2017 and first published on 27 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01374D
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Low pH-triggering changes in peptide secondary structures

    K. Furukawa, M. Oba, K. Toyama, G. O. Opiyo, Y. Demizu, M. Kurihara, M. Doi and M. Tanaka, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01374D

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