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Recent Advances in Asymmetric Total Synthesis of Prostaglandins

Abstract

Prostaglandins (PGs) are a series of hormone-like chemical messengers and play a critical role in regulating physiological activity. The diversified therapeutic activities and complex molecular architectures of PGs have attracted special attention and huge progress has been made in asymmetric total synthesis and discoveries of pharmaceutical useful drug candidates. In the last 10 years, several powerful syntheses have emerged as new solutions to the problem of building PGs and represent major breakthroughs in this area. This review highlights the advances of methodologies in the asymmetric total synthesis of prostaglandins. The application of these methodologies in the syntheses of medicinal useful prostaglandins are also described. The article has been carefully categorized according to the key procedures included in the syntheses of various prostaglandins, aiming to give readers an easy understanding of this chemistry and provide a clue for further improvements.

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Publication details

The article was received on 01 Jun 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Review Article
DOI: 10.1039/C7OB01341H
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Recent Advances in Asymmetric Total Synthesis of Prostaglandins

    F. E. Chen and H. Peng, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB01341H

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