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Recent advances in asymmetric total synthesis of prostaglandins

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Abstract

Prostaglandins (PGs) are a series of hormone-like chemical messengers and play a critical role in regulating physiological activity. The diversified therapeutic activities and complex molecular architectures of PGs have attracted special attention, and huge progress has been made in asymmetric total synthesis and discovery of pharmaceutically useful drug candidates. In the last 10 years, several powerful syntheses have emerged as new solutions to the problem of building PGs and represent major breakthroughs in this area. This review highlights the advances in methodologies for the asymmetric total synthesis of prostaglandins. The application of these methodologies in the syntheses of medicinally useful prostaglandins is also described. The study has been carefully categorized according to the key procedures involved in the syntheses of various prostaglandins, aiming to give readers an easy understanding of this chemistry and provide insights for further improvements.

Graphical abstract: Recent advances in asymmetric total synthesis of prostaglandins

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Publication details

The article was received on 01 Jun 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Review Article
DOI: 10.1039/C7OB01341H
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Recent advances in asymmetric total synthesis of prostaglandins

    H. Peng and F. Chen, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01341H

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