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Issue 28, 2017
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Copper-mediated trifluoroacetylation of indoles with ethyl trifluoropyruvate

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Abstract

Direct trifluoroacetylation of indoles with ethyl trifluoropyruvate as a trifluoroacetylating reagent has been developed. This novel protocol provides an attractive route for the preparation of 3-trifluoroacetylindole derivatives, due to its operational simplicity and practicability as well as mild reaction conditions.

Graphical abstract: Copper-mediated trifluoroacetylation of indoles with ethyl trifluoropyruvate

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Publication details

The article was received on 01 Jun 2017, accepted on 28 Jun 2017 and first published on 28 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01335C
Citation: Org. Biomol. Chem., 2017,15, 5904-5907
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    Copper-mediated trifluoroacetylation of indoles with ethyl trifluoropyruvate

    G. Yan, X. Cao, W. Zheng, Q. Ke, J. Zhang and D. Huang, Org. Biomol. Chem., 2017, 15, 5904
    DOI: 10.1039/C7OB01335C

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