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Issue 32, 2017
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Calcium carbide catalytically activated with tetra-n-butyl ammonium fluoride for Sonogashira cross coupling reactions

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Abstract

We report a novel method for the direct synthesis of mono- and bis-arylated alkynes utilizing catalytically activated CaC2 as the alkyne component. This fluoride-activated cross coupling reaction provides advantages over existing methods regarding operational simplicity, use of readily available starting materials, and low cost.

Graphical abstract: Calcium carbide catalytically activated with tetra-n-butyl ammonium fluoride for Sonogashira cross coupling reactions

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Publication details

The article was received on 31 May 2017, accepted on 25 Jul 2017 and first published on 25 Jul 2017


Article type: Paper
DOI: 10.1039/C7OB01334E
Citation: Org. Biomol. Chem., 2017,15, 6800-6807
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    Calcium carbide catalytically activated with tetra-n-butyl ammonium fluoride for Sonogashira cross coupling reactions

    A. Hosseini, A. Pilevar, E. Hogan, B. Mogwitz, A. S. Schulze and P. R. Schreiner, Org. Biomol. Chem., 2017, 15, 6800
    DOI: 10.1039/C7OB01334E

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