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Issue 27, 2017
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Copper-catalyzed decarboxylative methylthiolation of aromatic carboxylate salts with DMSO

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Abstract

A novel copper-catalyzed decarboxylative methylthiolation of arenecarboxylate salts has been realized using DMSO as the methylthiolation source. Various potassium aryl carboxylates underwent decarboxylative methylthiolation under air to furnish the corresponding aryl methyl thioethers in moderate to excellent yields. The reaction tolerated a wide variety of functional groups. Notably, the synthesis of ethylthioethers was also successfully achieved directly from diethyl sulfoxide under similar reaction conditions.

Graphical abstract: Copper-catalyzed decarboxylative methylthiolation of aromatic carboxylate salts with DMSO

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Publication details

The article was received on 30 May 2017, accepted on 19 Jun 2017 and first published on 19 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01315A
Citation: Org. Biomol. Chem., 2017,15, 5674-5679
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    Copper-catalyzed decarboxylative methylthiolation of aromatic carboxylate salts with DMSO

    L. Hu, D. Wang, X. Chen, L. Yu, Y. Yu, Z. Tan and G. Zhu, Org. Biomol. Chem., 2017, 15, 5674
    DOI: 10.1039/C7OB01315A

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