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Synthesis of trifluoromethylated pyrazolidines by [3 + 2] cycloaddition

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Abstract

A highly efficient [3 + 2] cycloaddition between trifluoromethylated N-acylhydrazones and nitroolefins in the presence of potassium hydroxide under phase transfer catalysis is developed to afford potentially bioactive trifluoromethylated pyrazolidines, which can be further transformed into trifluoromethylated pyrazoles in good yields.

Graphical abstract: Synthesis of trifluoromethylated pyrazolidines by [3 + 2] cycloaddition

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Publication details

The article was received on 27 May 2017, accepted on 04 Jul 2017 and first published on 04 Jul 2017


Article type: Paper
DOI: 10.1039/C7OB01299C
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Synthesis of trifluoromethylated pyrazolidines by [3 + 2] cycloaddition

    X. Peng, D. Huang, K. Wang, Y. Wang, J. Wang, Y. Su and Y. Hu, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01299C

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