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Driving and photo-regulation of myosin–actin motors at molecular and macroscopic levels by photo-responsive high energy molecules

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Abstract

We employed an azobenzene based non-nucleoside triphosphate, AzoTP, in a myosin–actin motile system and demonstrated its efficiency as an energy molecule to drive and photo-regulate the myosin–actin motile function at the macroscopic level along with an in vitro motility assay. The AzoTP in its trans state induced shortening of a glycerinated muscle fibre whilst a cis isomer had no significant effect. Direct photoirradiation of a cis-AzoTP infused muscle fibre induced shortening triggered by a locally photo-generated trans-AzoTP in the muscle fibre. Furthermore, we designed and synthesized three new derivatives of AzoTPs that served as substrates for myosin by driving and photo-regulating the myosin–actin motile function at the molecular as well as the macroscopic level with varied efficiencies.

Graphical abstract: Driving and photo-regulation of myosin–actin motors at molecular and macroscopic levels by photo-responsive high energy molecules

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Publication details

The article was received on 26 May 2017, accepted on 03 Sep 2017 and first published on 13 Sep 2017


Article type: Paper
DOI: 10.1039/C7OB01293D
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Driving and photo-regulation of myosin–actin motors at molecular and macroscopic levels by photo-responsive high energy molecules

    H. M. Menezes, Md. J. Islam, M. Takahashi and N. Tamaoki, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01293D

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