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Issue 30, 2017
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Selective construction of polycyclic spirooxindoles via a Cu(OTf)2/HOTf-catalyzed domino reaction of o-arylalkynylacetophenones and 3-phenacylideneoxindoles

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Abstract

Under the combined catalysis of Cu(OTf)2/HOTf, the domino annulation reaction of o-arylalkynyl acetophenones with 3-phenacylideneoxindoles in refluxing acetonitrile selectively afforded functionalized spiro[indoline-3,7′-tetrapheno[7,6-bc]furans] and spiro[indeno[1,2-b]naphtho[2,1-d]furan-7,3′-indolines] depending on the electronic effect of the substituents on both substrates.

Graphical abstract: Selective construction of polycyclic spirooxindoles via a Cu(OTf)2/HOTf-catalyzed domino reaction of o-arylalkynylacetophenones and 3-phenacylideneoxindoles

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Publication details

The article was received on 26 May 2017, accepted on 01 Jul 2017 and first published on 03 Jul 2017


Article type: Paper
DOI: 10.1039/C7OB01292F
Citation: Org. Biomol. Chem., 2017,15, 6353-6357
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    Selective construction of polycyclic spirooxindoles via a Cu(OTf)2/HOTf-catalyzed domino reaction of o-arylalkynylacetophenones and 3-phenacylideneoxindoles

    R. Yang, J. Sun, Q. Sun and C. Yan, Org. Biomol. Chem., 2017, 15, 6353
    DOI: 10.1039/C7OB01292F

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