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Gold-catalyzed intramolecular cyclization/condensation sequence: synthesis of 1,2-dihydro[c][2,7]naphthyridines

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Abstract

An efficient gold-catalyzed synthetic protocol for the construction of 1,2-dihydro[c][2,7]naphthyridines from 2-aminophenyl prop-2-yn-1-yl enaminones has been developed. In this organic transformation new C–C and C–N bond formations occur via 6-endo-dig cyclization and condensation. 1,2-Dihydro[c][2,7]naphthyridine derivatives were obtained in good to excellent yields in a one-pot synthesis at ambient temperature.

Graphical abstract: Gold-catalyzed intramolecular cyclization/condensation sequence: synthesis of 1,2-dihydro[c][2,7]naphthyridines

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Publication details

The article was received on 25 May 2017, accepted on 25 Aug 2017 and first published on 25 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01285C
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Gold-catalyzed intramolecular cyclization/condensation sequence: synthesis of 1,2-dihydro[c][2,7]naphthyridines

    K. Goutham, V. Kadiyala, B. Sridhar and G. V. Karunakar, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01285C

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