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Ruthenium-catalyzed site-selective C–H arylation of 2-pyridones and 1-isoquinolinones

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Abstract

An efficient Ru(II)-catalyzed site-selective C–H arylation of 2-pyridones and 1-isoquinolinones was achieved with boronic acids by using pyridine as a directing group. The developed protocol is general and provides rapid access to an array of C6-arylated 2-pyridones and C3-arylated 1-isoquinolinones in excellent yields. These designed arylated 2-pyridones and 1-isoquinolinones can serve as key structural motifs for accessing functionalized pyridines and isoquinolines.

Graphical abstract: Ruthenium-catalyzed site-selective C–H arylation of 2-pyridones and 1-isoquinolinones

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Publication details

The article was received on 24 May 2017, accepted on 11 Jun 2017 and first published on 12 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01277B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Ruthenium-catalyzed site-selective C–H arylation of 2-pyridones and 1-isoquinolinones

    K. Anil Kumar, P. Kannaboina and P. Das, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01277B

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