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Governing Effects in the Mechanism of the Gold--Catalyzed Cycloisomerization of Allenic Hydroxylamine Derivatives

Abstract

The formation of chiral heterocycles via cycloisomerization reactions of allene derivatives has gained relevance due to its associated efficient and atom-economy. The only drawback that keeps these reactions away from being routine synthetic strategies is the control in the regioselectivity (most often 5-endo vs 6-endo). In this work we computationally explore the experimental chemistry reported by Krause using N-hydroxy-α-aminoallenes and hydroxylamine ethers as substrates and provide a rationale for the different reactivity observed. The drastic effects observed experimentally when changing the nature of the gold catalyst have also been studied mechanistically. These results are expected to help in the design of improved regioselective protocols for the formation of medium sized chiral heterocycles from allene substrates.

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Publication details

The article was received on 24 May 2017, accepted on 16 Jun 2017 and first published on 16 Jun 2017


Article type: Paper
DOI: 10.1039/C7OB01275F
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Governing Effects in the Mechanism of the Gold--Catalyzed Cycloisomerization of Allenic Hydroxylamine Derivatives

    C. S. Lopez, O. Nieto Faza, A. Kolocouris and S. Kiriakidi, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB01275F

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