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Silver-catalyzed [3 + 2] domino reaction: an efficient strategy to synthesize imidazole-5-carbaldehydes

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Abstract

An unprecedented regioselective silver-catalyzed [3 + 2] domino reaction of amidines and ynals for the formation of C–N bonds has been developed. The reaction provided a new route to prepare imidazole-5-carbaldehydes which are important intermediates for the construction of fine chemicals. The reaction proceeds smoothly with a broad range of substrates to give imidazoles in good yields.

Graphical abstract: Silver-catalyzed [3 + 2] domino reaction: an efficient strategy to synthesize imidazole-5-carbaldehydes

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Publication details

The article was received on 22 May 2017, accepted on 14 Jun 2017 and first published on 15 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01242J
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Silver-catalyzed [3 + 2] domino reaction: an efficient strategy to synthesize imidazole-5-carbaldehydes

    C. Wang, H. Jiang, W. Chen, J. Dong, Z. Chen and H. Cao, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01242J

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