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Ru-Catalyzed asymmetric transfer hydrogenation of substituted dibenzo[b,f][1,4]oxazepines in water

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Abstract

This is the first report on the asymmetric transfer hydrogenation (ATH) of dibenzo[b,f][1,4]oxazepine compounds in the presence of an (R,R)-Ru-Ts-DPEN complex. The developed catalytic asymmetric protocol provides biologically active 11-substituted-10,11-dihydrodibenzo[b,f][1,4]oxazepines with excellent conversion (up to >99%) and high enantioselectivity (up to 93% ee) in water as an environmentally benign solvent.

Graphical abstract: Ru-Catalyzed asymmetric transfer hydrogenation of substituted dibenzo[b,f][1,4]oxazepines in water

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Publication details

The article was received on 18 May 2017, accepted on 06 Jun 2017 and first published on 14 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01229B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Ru-Catalyzed asymmetric transfer hydrogenation of substituted dibenzo[b,f][1,4]oxazepines in water

    G. V. More and B. M. Bhanage, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01229B

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