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Comment on “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model” by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407

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Abstract

It has been proved that the reaction between furfuryl amines and N-R-maleimides leads to the formation of aza-Michael addition products – 3-(furylmethylamino)-N-R-pyrrolidine-2,5-diones, instead of 7-oxa-2-azabicyclo[2.2.1]hept-5-enes, as this journal reported previously.

Graphical abstract: Comment on “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model” by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407

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Publication details

The article was received on 17 May 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Comment
DOI: 10.1039/C7OB01207A
Citation: Org. Biomol. Chem., 2017, Advance Article
  • Open access: Creative Commons BY license
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    Comment on “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model” by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407

    F. I. Zubkov, E. A. Kvyatkovskaya, E. V. Nikitina, P. N.-A. Amoyaw, V. V. Kouznetsov, V. A. Lazarenko and V. N. Khrustalev, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01207A

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