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Synthesis of lipo-chitooligosaccharide analogues and their interaction with LYR3, a high affinity binding protein for Nod factors and Myc-LCOs

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Abstract

Lipo-chitotetrasaccharide analogues where one central GlcNAc residue was replaced by a triazole unit have been synthesized from a derivative obtained by chitin depolymerization and a functionalized N-acetyl-glucosamine via the copper-catalyzed azide–alkyne cycloaddition. Their evaluation in a binding assay using LYR3, a putative lipo-chitooligosaccharide receptor in Medicago truncatula, shows a complete loss of binding.

Graphical abstract: Synthesis of lipo-chitooligosaccharide analogues and their interaction with LYR3, a high affinity binding protein for Nod factors and Myc-LCOs

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Publication details

The article was received on 17 May 2017, accepted on 30 Aug 2017 and first published on 30 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01201B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Synthesis of lipo-chitooligosaccharide analogues and their interaction with LYR3, a high affinity binding protein for Nod factors and Myc-LCOs

    N. Berthelot, A. Brossay, V. Gasciolli, J. Bono, A. Baron, J. Beau, D. Urban, F. Boyer and B. Vauzeilles, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01201B

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