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Issue 27, 2017
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Application of a 2-aryl indenylphosphine ligand in the Buchwald–Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions

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Abstract

An efficient solvent-free protocol for the Buchwald–Hartwig cross-coupling reaction of aryl and heteroaryl chlorides with primary and secondary amines using the Pd(dba)2/ligand 1 catalytic system has been developed. Notably, the catalytic system also efficiently catalyzed the reaction under aqueous conditions.

Graphical abstract: Application of a 2-aryl indenylphosphine ligand in the Buchwald–Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions

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Publication details

The article was received on 08 Feb 2017, accepted on 06 Jun 2017 and first published on 19 Jun 2017


Article type: Paper
DOI: 10.1039/C7OB01199G
Citation: Org. Biomol. Chem., 2017,15, 5805-5810
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    Application of a 2-aryl indenylphosphine ligand in the Buchwald–Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions

    Y. Liu, J. Yuan, Z. Wang, S. Zeng, M. Gao, M. Ruan, J. Chen and G. Yu, Org. Biomol. Chem., 2017, 15, 5805
    DOI: 10.1039/C7OB01199G

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