Jump to main content
Jump to site search

Issue 36, 2017
Previous Article Next Article

Cu(II)-Mediated keto C(sp3)–H bond α-acyloxylation of N,N-dialkylamides with aromatic carboxylic acids

Author affiliations

Abstract

The selective oxidative coupling of aromatic carboxylic acids with the C(sp3)–H bond adjacent to the keto group of alkylamides has been developed by employing a low cost copper source. This provides an efficient approach for synthesis of O-benzoylglycolamides. The protocol displayed good functional group tolerance. A broad range of benzoic acids directly coupled with alkylamides to afford a variety of O-benzoylglycolamides in moderate to good yields. In addition, a reasonable radical mechanism was proposed based on EPR experiments.

Graphical abstract: Cu(ii)-Mediated keto C(sp3)–H bond α-acyloxylation of N,N-dialkylamides with aromatic carboxylic acids

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 May 2017, accepted on 11 Jul 2017 and first published on 11 Jul 2017


Article type: Paper
DOI: 10.1039/C7OB01190C
Citation: Org. Biomol. Chem., 2017,15, 7594-7599
  •   Request permissions

    Cu(II)-Mediated keto C(sp3)–H bond α-acyloxylation of N,N-dialkylamides with aromatic carboxylic acids

    W. Li, C. Yin, X. Yang, H. Liu, X. Zheng, M. Yuan, R. Li, H. Fu and H. Chen, Org. Biomol. Chem., 2017, 15, 7594
    DOI: 10.1039/C7OB01190C

Search articles by author

Spotlight

Advertisements