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Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems

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Abstract

An investigation of the formation of fused- and spiro-β-lactone annulate to γ-lactams has shown that the fused systems are formed preferentially, under standard conditions, but that spiro systems are accessible only when the formation of the fused system is blocked and require careful optimisation of reaction conditions. These systems display both weak antibacterial activity and proteasome inhibition.

Graphical abstract: Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems

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Publication details

The article was received on 10 May 2017, accepted on 05 Jun 2017 and first published on 05 Jun 2017


Article type: Paper
DOI: 10.1039/C7OB01148B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems

    L. Josa-Culleré, C. Towers, F. Willenbrock, V. M. Macaulay, K. E. Christensen and M. G. Moloney, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01148B

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