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Issue 24, 2017
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Pd-Catalyzed regioselective sequential meta-, ortho-C–H functionalization of arenes: a predictable approach to the synthesis of polysubstituted β-arylethylamines

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Abstract

With the assistance of the same bidentate directing group, the first example of sequential, controllable C–H functionalization of β-arylethylamines at different positions for the construction of polysubstituted arenes is reported. Pd-Catalyzed highly regioselective ortho-C–H functionalization reactions of meta-aryl substituted arylethylamines are performed, including alkynylation, iodination, acetoxylation and amination, which led to a concise approach to the synthesis of polysubstituted β-arylethylamine derivatives.

Graphical abstract: Pd-Catalyzed regioselective sequential meta-, ortho-C–H functionalization of arenes: a predictable approach to the synthesis of polysubstituted β-arylethylamines

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Publication details

The article was received on 09 May 2017, accepted on 26 May 2017 and first published on 30 May 2017


Article type: Communication
DOI: 10.1039/C7OB01135K
Citation: Org. Biomol. Chem., 2017,15, 5112-5116
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    Pd-Catalyzed regioselective sequential meta-, ortho-C–H functionalization of arenes: a predictable approach to the synthesis of polysubstituted β-arylethylamines

    J. Han, N. Wang, Z. Huang, Y. Zhao and D. Shi, Org. Biomol. Chem., 2017, 15, 5112
    DOI: 10.1039/C7OB01135K

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