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Issue 21, 2017
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In situ generation of less accessible Boc-imines from aldehydes: construction of a quaternary carbon by the Mannich reaction or unprecedented aldol reaction

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Abstract

In situ generation of less accessible N-Boc-protected imines from aldehydes and their application to the direct three-component Mannich reaction with β-dicarbonyls were realized. The catalyst-free aldol reaction of ynals with β-dicarbonyls was also developed.

Graphical abstract: In situ generation of less accessible Boc-imines from aldehydes: construction of a quaternary carbon by the Mannich reaction or unprecedented aldol reaction

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Publication details

The article was received on 08 May 2017, accepted on 09 May 2017 and first published on 09 May 2017


Article type: Communication
DOI: 10.1039/C7OB01126A
Citation: Org. Biomol. Chem., 2017,15, 4527-4530
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    In situ generation of less accessible Boc-imines from aldehydes: construction of a quaternary carbon by the Mannich reaction or unprecedented aldol reaction

    T. Kano, C. Homma and K. Maruoka, Org. Biomol. Chem., 2017, 15, 4527
    DOI: 10.1039/C7OB01126A

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