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Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A

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Abstract

Synthesis of the antimicrobial marine natural product halocyamine A has been achieved utilizing a combination of Sonogashira coupling, ruthenium complex/ytterbium triflate catalyzed hydroamidation and solid-phase peptide synthesis (SPPS) chemistry. The synthetic natural product exhibited only modest levels of antibacterial activities but significant antioxidant activity.

Graphical abstract: Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A

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Publication details

The article was received on 08 May 2017, accepted on 04 Jul 2017 and first published on 04 Jul 2017


Article type: Paper
DOI: 10.1039/C7OB01122A
Citation: Org. Biomol. Chem., 2017, Advance Article
  • Open access: Creative Commons BY-NC license
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    Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A

    H. K. H. Fong, J. M. Brunel, A. Longeon, M. Bourguet-Kondracki, D. Barker and B. R. Copp, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01122A

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