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Synthesis of seven-membered heterocycles via copper-catalyzed cross-coupling of terminal alkynes with diazo compounds and sequential Michael addition

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Abstract

A novel approach to synthesize seven-membered heterocycles is established by reacting amide tethered terminal alkynes with aryl diazoacetates in a one-pot reaction. This reaction involves copper-catalyzed cross coupling followed by base-promoted intramolecular Michael addition and yields products with a medium-sized ring.

Graphical abstract: Synthesis of seven-membered heterocycles via copper-catalyzed cross-coupling of terminal alkynes with diazo compounds and sequential Michael addition

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Publication details

The article was received on 04 May 2017, accepted on 07 Jun 2017 and first published on 07 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01091E
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Synthesis of seven-membered heterocycles via copper-catalyzed cross-coupling of terminal alkynes with diazo compounds and sequential Michael addition

    S. Yan, S. Cao and J. Sun, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01091E

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