Jump to main content
Jump to site search

Issue 27, 2017
Previous Article Next Article

Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)

Author affiliations

Abstract

Here we show the first example of an immunoreceptor tyrosine-based inhibitory motif (ITIM), LYYYYL, as well as its enantiomeric or retro-inverso peptide, to self-assemble in water via enzyme-instructed self-assembly. Upon enzymatic dephosphorylation, the phosphohexapeptides become hexapeptides, which self-assemble in water to result in supramolecular hydrogels. This work illustrates a new approach to design bioinspired soft materials from a less explored, but important pool of immunomodulatory peptides.

Graphical abstract: Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 May 2017, accepted on 22 Jun 2017 and first published on 26 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01074E
Citation: Org. Biomol. Chem., 2017,15, 5689-5692
  •   Request permissions

    Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)

    N. Yamagata, X. Chen, J. Zhou, J. Li, X. Du and B. Xu, Org. Biomol. Chem., 2017, 15, 5689
    DOI: 10.1039/C7OB01074E

Search articles by author

Spotlight

Advertisements