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Issue 28, 2017
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Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions

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Abstract

Collagen mimetic peptides that alone formed two-dimensional nanoscale discs driven by hydrophobic interactions were shown in electron microscopy studies to also co-assemble with natural fibrous proteins to produce discs-on-a-string (DoS) nanostructures. In most cases, peptide discs also facilitated bundling of the protein fibers. This provides insight into how synthetic and natural proteins may be combined to develop multicomponent, multi-dimensional architectures at the nanoscale.

Graphical abstract: Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions

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Publication details

The article was received on 03 May 2017, accepted on 28 Jun 2017 and first published on 29 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01073G
Citation: Org. Biomol. Chem., 2017,15, 5893-5898
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    Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions

    K. McGuinness and V. Nanda, Org. Biomol. Chem., 2017, 15, 5893
    DOI: 10.1039/C7OB01073G

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