Jump to main content
Jump to site search

Issue 22, 2017
Previous Article Next Article

Diastereo- and enantioselective construction of spirooxindole scaffolds through a catalytic asymmetric [3 + 3] cycloaddition

Author affiliations

Abstract

A chiral phosphoric acid-catalyzed asymmetric [3 + 3] cycloaddition of C3-substituted 2-indolylmethanols with isatin-derived azomethine ylides has been established, which afforded chiral spirooxindoles in considerable yields, moderate to good enantioselectivities and excellent diastereoselectivities (up to 85% yield, 96 : 4 er, all >95 : 5 dr).

Graphical abstract: Diastereo- and enantioselective construction of spirooxindole scaffolds through a catalytic asymmetric [3 + 3] cycloaddition

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 May 2017, accepted on 16 May 2017 and first published on 16 May 2017


Article type: Communication
DOI: 10.1039/C7OB01059A
Citation: Org. Biomol. Chem., 2017,15, 4794-4797
  •   Request permissions

    Diastereo- and enantioselective construction of spirooxindole scaffolds through a catalytic asymmetric [3 + 3] cycloaddition

    C. Li, H. Lu, X. Sun, G. Mei and F. Shi, Org. Biomol. Chem., 2017, 15, 4794
    DOI: 10.1039/C7OB01059A

Search articles by author

Spotlight

Advertisements