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Is more better? A comparison of tri- and tetrapeptidic catalysts

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Abstract

From an enzymatic perspective, there is a general notion that the bigger and more complex a catalytically active peptide is the more enzyme-like and the better it should become. But is this really true? We have tackled this question firstly by screening split-and-mix-libraries of tri- and tetrapeptides for members that catalyze aldol reactions. Then, the catalytic performance of all possible diastereoisomers of related tri- and tetrapeptidic catalysts of the type H-Pro-Pro-Glu/Asp-NH2 and H-Pro-Pro-Glu/Asp-Pro-NH2 in aldol and conjugate addition reactions was compared.

Graphical abstract: Is more better? A comparison of tri- and tetrapeptidic catalysts

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Publication details

The article was received on 28 Apr 2017, accepted on 20 May 2017 and first published on 22 May 2017


Article type: Communication
DOI: 10.1039/C7OB01039G
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Is more better? A comparison of tri- and tetrapeptidic catalysts

    T. Schnitzer, M. Wiesner, P. Krattiger, J. D. Revell and H. Wennemers, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01039G

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