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Issue 25, 2017
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An efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via sequential α-arylation of carbonyl and deacylation catalyzed by CuI

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Abstract

Dibenzoyl methane was found to undergo α-arylation of carbonyl and deacylation reaction with 2-(2-bromophenyl)-1H-benzo[d]imidazoles catalyzed by CuI in the presence of Cs2CO3, and provided an efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via subsequent intra-molecular nucleophilic addition and dehydration.

Graphical abstract: An efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via sequential α-arylation of carbonyl and deacylation catalyzed by CuI

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Publication details

The article was received on 27 Apr 2017, accepted on 06 Jun 2017 and first published on 07 Jun 2017


Article type: Paper
DOI: 10.1039/C7OB01022B
Citation: Org. Biomol. Chem., 2017,15, 5325-5331
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    An efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via sequential α-arylation of carbonyl and deacylation catalyzed by CuI

    W. Miao, J. Liu and X. Wang, Org. Biomol. Chem., 2017, 15, 5325
    DOI: 10.1039/C7OB01022B

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