Issue 26, 2017

Copper(ii) catalyzed iodine-promoted oxidative cyclization of 2-amino-1,3,5-triazines and chalcones: synthesis of aroylimidazo[1,2-a][1,3,5]triazines

Abstract

An efficient copper(II) catalyzed iodine-promoted synthesis of aroylimidazo[1,2-a][1,3,5]triazines from 2-amino-1,3,5-triazines and chalcones under mild conditions has been developed. The reaction occurred with good yields and excellent regioselectivities, and tolerated chalcone containing functionalities such as ethers, halogens, and nitro groups. The successful application of this methodology for a gram-scale reaction indicates its potential for bulk synthesis.

Graphical abstract: Copper(ii) catalyzed iodine-promoted oxidative cyclization of 2-amino-1,3,5-triazines and chalcones: synthesis of aroylimidazo[1,2-a][1,3,5]triazines

Supplementary files

Article information

Article type
Paper
Submitted
26 Apr 2017
Accepted
14 Jun 2017
First published
14 Jun 2017

Org. Biomol. Chem., 2017,15, 5564-5570

Copper(II) catalyzed iodine-promoted oxidative cyclization of 2-amino-1,3,5-triazines and chalcones: synthesis of aroylimidazo[1,2-a][1,3,5]triazines

J. J. Li, C. Song, D. Cui and C. Zhang, Org. Biomol. Chem., 2017, 15, 5564 DOI: 10.1039/C7OB01018D

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