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Issue 21, 2017
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Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction

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Abstract

An organocatalytic asymmetric method for the synthesis of 2-CF3 tetrahydroquinoline has been achieved. The cascade reaction of 2-aminochalcones with β-CF3 nitroalkenes afforded the products bearing three contiguous stereogenic centers in good yields with excellent diastereoselectivities and enantioselectivities.

Graphical abstract: Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction

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Publication details

The article was received on 26 Apr 2017, accepted on 11 May 2017 and first published on 11 May 2017


Article type: Communication
DOI: 10.1039/C7OB01013C
Citation: Org. Biomol. Chem., 2017,15, 4544-4547
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    Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction

    Y. Zhu, B. Li, C. Wang, Z. Dong, X. Zhong, K. Wang, W. Yan and R. Wang, Org. Biomol. Chem., 2017, 15, 4544
    DOI: 10.1039/C7OB01013C

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