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Issue 22, 2017
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Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

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Abstract

Neobraclactones A–C (1–3), featuring an unprecedented further rearranged prenylxanthone skeleton with a unique octahydro-2H-1,3-dioxacyclopenta[c,d]inden-2-one scaffold, along with their biosynthesis-related known compound neobractatin (4), were isolated from the leaves of Garcinia bracteata. Their structures with absolute configurations were determined by extensive analyses of spectroscopic data and ECD calculations. Compounds 1 and 2 showed significant growth inhibition activities against the human leukaemia HL-60 and K562 cell lines with GI50 values from 0.40 to 0.86 μM.

Graphical abstract: Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

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Publication details

The article was received on 25 Apr 2017, accepted on 18 May 2017 and first published on 18 May 2017


Article type: Paper
DOI: 10.1039/C7OB01007A
Citation: Org. Biomol. Chem., 2017,15, 4901-4906
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    Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

    S. Niu, D. Li, Y. Wang, K. Wang, B. Lin, Y. Jing, H. Hua, J. Bai and Z. Li, Org. Biomol. Chem., 2017, 15, 4901
    DOI: 10.1039/C7OB01007A

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