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Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

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Abstract

Neobraclactones A–C (1–3), featuring an unprecedented further rearranged prenylxanthone skeleton with a unique octahydro-2H-1,3-dioxacyclopenta[c,d]inden-2-one scaffold, along with their biosynthesis-related known compound neobractatin (4), were isolated from the leaves of Garcinia bracteata. Their structures with absolute configurations were determined by extensive analyses of spectroscopic data and ECD calculations. Compounds 1 and 2 showed significant growth inhibition activities against the human leukaemia HL-60 and K562 cell lines with GI50 values from 0.40 to 0.86 μM.

Graphical abstract: Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

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Publication details

The article was received on 25 Apr 2017, accepted on 18 May 2017 and first published on 18 May 2017


Article type: Paper
DOI: 10.1039/C7OB01007A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

    S. Niu, D. Li, Y. Wang, K. Wang, B. Lin, Y. Jing, H. Hua, J. Bai and Z. Li, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01007A

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