Jump to main content
Jump to site search


Re-characterization of hammerhead ribozymes as molecular tools for intermolecular RNA cleavage

Author affiliations

Abstract

A new guideline for the construction of hammerhead ribozymes to achieve trans-cleavage of a single-stranded RNA molecule was developed. The sequence rule of the HHRz cleavage site was highly recommended to be “DWH” with an optimal binding arm length of 8–9nt, which diverged from the former rule of “NUX”.

Graphical abstract: Re-characterization of hammerhead ribozymes as molecular tools for intermolecular RNA cleavage

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 24 Apr 2017, accepted on 09 May 2017 and first published on 09 May 2017


Article type: Paper
DOI: 10.1039/C7OB00995J
Citation: Org. Biomol. Chem., 2017, Advance Article
  •   Request permissions

    Re-characterization of hammerhead ribozymes as molecular tools for intermolecular RNA cleavage

    G. Liu, X. Huang, Q. Pu, Y. Zhao, F. Du, J. Dong, X. Cui and Z. Tang, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB00995J

Search articles by author