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Issue 21, 2017
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Re-characterization of hammerhead ribozymes as molecular tools for intermolecular RNA cleavage

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Abstract

A new guideline for the construction of hammerhead ribozymes to achieve trans-cleavage of a single-stranded RNA molecule was developed. The sequence rule of the HHRz cleavage site was highly recommended to be “DWH” with an optimal binding arm length of 8–9nt, which diverged from the former rule of “NUX”.

Graphical abstract: Re-characterization of hammerhead ribozymes as molecular tools for intermolecular RNA cleavage

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Publication details

The article was received on 24 Apr 2017, accepted on 09 May 2017 and first published on 09 May 2017


Article type: Paper
DOI: 10.1039/C7OB00995J
Citation: Org. Biomol. Chem., 2017,15, 4681-4685
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    Re-characterization of hammerhead ribozymes as molecular tools for intermolecular RNA cleavage

    G. Liu, X. Huang, Q. Pu, Y. Zhao, F. Du, J. Dong, X. Cui and Z. Tang, Org. Biomol. Chem., 2017, 15, 4681
    DOI: 10.1039/C7OB00995J

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