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A new strategy of copper-catalyzed one–pot synthesis of 1,2-disubstituted benzimidazoles

Abstract

A simple, one-pot and copper-catalyzed coupling reaction for the construction of 1,2-disubstituted benzimidazole derivatives is described. Low-cost copper salt and weak base K3PO4 were utlized in this reaction. A variety of 1,2-disubstituted benzimidazoles were obtained in moderate to excellent yields.

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Publication details

The article was received on 18 Apr 2017, accepted on 14 Jun 2017 and first published on 14 Jun 2017


Article type: Paper
DOI: 10.1039/C7OB00945C
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    A new strategy of copper-catalyzed one–pot synthesis of 1,2-disubstituted benzimidazoles

    C. Xie, X. Han, J. Gong, D. Li and C. Ma, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB00945C

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