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Issue 27, 2017
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One-pot strategy of copper-catalyzed synthesis of 1,2-disubstituted benzimidazoles

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Abstract

A simple, one-pot and copper-catalyzed coupling reaction for the construction of 1,2-disubstituted benzimidazole derivatives is described. A low-cost copper salt and a weak base K3PO4 were utilized in this reaction. A variety of 1,2-disubstituted benzimidazoles were obtained in moderate to excellent yields.

Graphical abstract: One-pot strategy of copper-catalyzed synthesis of 1,2-disubstituted benzimidazoles

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Publication details

The article was received on 18 Apr 2017, accepted on 14 Jun 2017 and first published on 14 Jun 2017


Article type: Paper
DOI: 10.1039/C7OB00945C
Citation: Org. Biomol. Chem., 2017,15, 5811-5819
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    One-pot strategy of copper-catalyzed synthesis of 1,2-disubstituted benzimidazoles

    C. Xie, X. Han, J. Gong, D. Li and C. Ma, Org. Biomol. Chem., 2017, 15, 5811
    DOI: 10.1039/C7OB00945C

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