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Issue 20, 2017
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A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides: direct access to 1,4,5-trisubstituted 1,2,3-triazoles

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Abstract

A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides has been developed. This strategy could generate 1,4,5-trisubstituted 1,2,3-triazoles in high yields and regioselectivities in the presence of a 20 mol% N-heterocyclic carbene catalyst. A broad substrate scope of this process is also presented.

Graphical abstract: A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides: direct access to 1,4,5-trisubstituted 1,2,3-triazoles

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Publication details

The article was received on 12 Apr 2017, accepted on 03 May 2017 and first published on 03 May 2017


Article type: Communication
DOI: 10.1039/C7OB00906B
Citation: Org. Biomol. Chem., 2017,15, 4286-4290
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    A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides: direct access to 1,4,5-trisubstituted 1,2,3-triazoles

    H. Yuan, L. Zhang, Z. Liu, Y. Liu, J. Wang and W. Li, Org. Biomol. Chem., 2017, 15, 4286
    DOI: 10.1039/C7OB00906B

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