Jump to main content
Jump to site search

Issue 18, 2017
Previous Article Next Article

Regioselective 1,2-addition of allenamides with N-haloimides: synthesis of 2-halo allylic aminal derivatives

Author affiliations

Abstract

A strategy for the synthesis of 2-halo allylic aminal derivatives through regioselective 1,2-addition of allenamides with N-haloimides is presented. This reaction was conducted under very mild conditions and gave up to 99% yield. Moreover, the obtained halides allow functional group diversification by palladium-catalyzed coupling reactions, which could act as potential intermediates for the synthesis of valuable compounds.

Graphical abstract: Regioselective 1,2-addition of allenamides with N-haloimides: synthesis of 2-halo allylic aminal derivatives

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 09 Apr 2017, accepted on 19 Apr 2017 and first published on 19 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00882A
Citation: Org. Biomol. Chem., 2017,15, 4005-4013
  •   Request permissions

    Regioselective 1,2-addition of allenamides with N-haloimides: synthesis of 2-halo allylic aminal derivatives

    H. Li, X. Li, Z. Zhao, X. Yuan and C. Sun, Org. Biomol. Chem., 2017, 15, 4005
    DOI: 10.1039/C7OB00882A

Search articles by author