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Regioselective 1,2-additon of allenamides with N-haloimides: synthesis of 2-halo allylic aminal derivatives

Abstract

A strategy for the synthesis of 2-halo allylic aminal derivatives through regioselective 1,2-addition of allenamides with N-haloimides is presented. This reaction was conducted under very mild conditions and gave up to 99% yield. Moreover, the obtained halides allow functional group diversification by palladium-catalyzed coupling reactions, which could act as potential intermediates for the synthesis of valuable compounds

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Publication details

The article was received on 09 Apr 2017, accepted on 19 Apr 2017 and first published on 19 Apr 2017


Article type: Paper
DOI: 10.1039/C7OB00882A
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Regioselective 1,2-additon of allenamides with N-haloimides: synthesis of 2-halo allylic aminal derivatives

    H. Li, X. Li, Z. Zhao, X. Yuan and C. Sun, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB00882A

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